The Ageing Limbs theme comprises a multi-disciplinary research group working on a variety of musculoskeletal and inflammatory diseases that afflict the elderly including rheumatoid arthritis (RA), osteoarthritis (OA), primary sjogren’s syndrome (PSS), and systemic sclerosis (SS).
Within these disease areas we perform laboratory research on diseased tissue to study pathogenic mechanisms, and to identify novel therapeutic targets and biomarkers; we also perform clinical trials both in collaboration with industrial partners and investigator-initiated, including some therapies developed in-house. Our technologies include clinical genetics and epigenetics, cellular and molecular immunology and inflammation, and biochemistry including intracellular signalling pathways.
We also host an Arthritis Research UK Centre of Excellence in Tissue Engineering, the Medical Research Council/Arthritis Research UK Centre of Excellence for Integrated Musculoskeletal Ageing (jointly with Universities of Sheffield and Liverpool), the MRC UK Primary Sjogren’s Syndrome Registry and an Arthritis Research UK Experimental Arthritis Treatment Centre.
Professor John Isaacs leads the NIHR Biomedical Research Centre's research into Ageing Limbs.Read more
Professor John Isaacs shares his vision for the future of research and tells the story of the patient who changed his life.
Rheumatoid arthritis (RA) is a chronic, painful, inflammatory disease which typically affects the small joints of the hands and feet.